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HelpTest Code ANORA - MISC Anora Miscarriage Test for Products of Conception (POC)
Useful For
To determine if a chromosomal abnormality was the likely cause of miscarriage.
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
|---|---|---|---|---|---|
| No | Blood | EDTA Lavender Top Tube (LTT) | 6 mL |
5 mL |
|
| No | Tissue (chorionic vill, gestational sac, fetal skin/tissue, umbilical cord tissue or cytogenetic tissue cell pellets) | Sterile Container - provided with kit |
|
|
0.5 mm |
Collection/Processing Instructions
Use Anora kit. Kits are stocked in following locations: Marshfield Lab Specimen Processing, and Labs at: Weston, Neillsville, Eau Claire, Beaver Dam, MMC-Dickinson, Park Falls, Ladysmith, Minocqua, Rice Lake, Stevens Point. In Marshfield, call 16226 to request.
The blood sample is helpful to rule out maternal cell contamination. Tissue and patient samples should be placed in saline, not formalin, and they should be shipped to Natera as soon as possible. Tissue samples should be stored in the refrigerator (not frozen) until the next shipping day. The blood tube (EDTA purple top tube) can also be stored in the refrigerator until shipping. Ship at ambient temperature, blood and tissue. DO NOT freeze.
Tissue collection tip:
Separate chorionic villi from blood clots and decidua to include only chorionic villi to reduce chance of maternal cell contamination. Refer to tissue sorting and sample collection instructions included in the kit. Sorting samples is however not required.
Cord blood samples should be drawn into an EDTA (LTT), and the tube should be labeled as "cord/fetal blood". Cord tissue or fetal skin can be placed in the saline POC cup provided with the Anora kit.
Specimen Stability Information
| Specimen Type | Temperature |
Time |
|---|---|---|
| Blood | Refrigerated |
14 days |
| Tissue | Refrigerated | 30 days |
Rejection Criteria
POC samples sent more than 30 days after collection and parental blood samples sent more than 14 days after collection cannot be accepted.
Tissue and patient samples should be placed in saline, NOT formalin.
Interferences
Anora cannot detect balanced chromosome rearragements (Inversions or balanced translocations). Balanced rearrangements are not a cause of miscarriage, but they can be incidental findings on traditional karyotypes.
Interpretations
An interpretive report will be provided.
Reference Range Information
An interpretive report will be provided.
Performing Laboratory Name
Natera, Inc.
Referral Laboratory Information
| Address | Telephone | Website Link | Marshfield Lab Account # |
|---|---|---|---|
|
201 Industrial Road Suite 410 San Carlos, CA 94070-2396 |
650-249-9090 |
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Natera, Inc. | Monday through Friday | 7 days | Single Nucleotide Polymorphism (SNP) microarray |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 81229 | 1 |