Home
HelpTest Code AS Hepatitis Panel, Acute
Useful For
In the diagnosis of acute viral hepatitis caused by the three most common viruses in the USA: hepatitis A, hepatitis B, & hepatitis C.
Synonyms/Keywords
Panel, Hepatitis Acute
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Serum Separator Tube (SST) | Red Top Tube (RTT) | 2 mL | 1.5 mL | 1 mL |
Collection/Processing Instructions
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube.
Specimen must be free of particulate matter including fibrin.
Regional/Outreach sites: Please send samples to Marshfield frozen.
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
|
Serum |
Ambient | <8 hours |
| Refrigerate | <48 hours | |
| Frozen at -20 C | 6 months | |
| Frozen at -70 C | >6 months |
Rejection Criteria
| Grossly hemolyzed |
|---|
| Grossly icteric |
| Specimens containing precipitate |
| Cadaver specimens |
| Heat-inactivated specimens |
| Body fluids other than serum |
Test Components
Hepatitis A Antibody IgM, Hepatitis B Surface Antigen, Hepatitis B Core Antibody IgM and Hepatitis C Antibody.
Test Information
Acute hepatitis may be caused by viral infection, non-viral infection, or non-infectious causes. Hepatitis A is transmitted by the oral-fecal route, while hepatitis B & hepatitis C are primarily borne by blood and other body fluids. While all three viruses can cause acute viral hepatitis, only B & C can progress to a chronic infection.
Limitations:
- The results determined by different assays from different manufacturers can vary due to differences in assay specificities and cannot be used interchangeably.
- For other limitations consult individual test reference assay entries.
Interferences
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay (A-M, ABC-M, HAA).
Interpretations
Results may be interpreted as follows:
- Reactive hepatitis A IgM antibody is indicative of acute infection.
- Reactive hepatitis B surface antigen and reactive hepatitis B core IgM antibody results indicates acute hepatitis B infection.
- Reactive hepatitis B surface antigen and non-reactive hepatitis B core IgM antibody is indicative of chronic hepatitis B.
- Reactive hepatitis C antibody indicates either acute or chronic hepatitis C infection. The Hepatitis C Virus RNA, Quantitative test (test code HCVQT) may be used to detect ongoing viral replication.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Tests reported as "Reactive" or "Non-reactive" |
Marshfield Labs Performing Department
Marshfield Labs Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 1 day | Chemiluminometric Immunoassays/Siemens Centaur |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80074 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80074 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Hepatitis Panel, Acute |