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HelpTest Code B2IGG Beta 2 Glycoprotein 1, IgG
Useful For
This semi-quantitative test panel detects IgG antibodies to Beta-2 Glycoprotein toaid in the diagnosis of primary Antiphospholipid Syndrome (APS) and those secondary to systemic lupus erythematosus (SLE) or SLE-disorders.
Synonyms/Keywords
Anti-Phospholipid Antibodies, Antiphospholipid Antibodies, Antiphospholipid syndrome, APS, anti-B2-GP1 antibodies, Beta 2 glycoprotein, Beta-2 glycoprotein, Beta-2 GP1, systemic lupus erythematosus, SLE
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) | Serum Separator Tube (SST) | 1 mL | 0.5 mL | 0.5 mL |
Collection/Processing Instructions
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated | 7 days |
| Frozen | >7 days |
Rejection Criteria
| Gross hemolysis | |
|---|---|
| Gross lipemia | |
| Heat-inactivated samples |
Test Information
The B2IGG test utilizes multiplex flow immunoassay, a methodology that greatly resembles traditional EIA, but permits simultaneous detection and identification of many antibodies in a single tube.
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by the venous and/or arterial thrombosis, thrombocytopenia, recurrent fetal loss, and moderate-to-high titers of antiphospholipid (aPL) antibodies, lupus anticoagulant (LA), anti-Cardiolipin (aCL) antibodies, and anti-B2-GP1 antibodies. A definitive diagnosis of APS requires the presence of at least one clinical manifestation and one positive laboratory result. Due to the heterogeneous nature of aPL antibodies, combined measurements of ACL and B2GP1 antibodies may provide better sensitivity than either assay alone.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
Negative < 20 |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday, 0700 to 1600 | 2 to 4 hours | Multiplex Flow Immunoassay/BioRad Bioplex 2200 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86146 | 1 | Beta 2 Glycoprotein 1 IgG |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86146 | 1 | Beta 2 Glycoprotein 1 IgG |
Ordering Applications
| Ordering Application | Description |
|---|---|
| COM | Beta2 Glycoprotein 1 IgG |
| Cerner | Beta2 Glycoprotein 1 IgG |