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HelpTest Code BNP B-Type Natriuretic Peptide
Useful For
This test is used as an aid in the diagnosis of congestive heart failure.
Synonyms/Keywords
BNP, Brain-type Natriuretic peptide
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No |
Plasma (Performing Sites - All Hospital Labs, except Weston and Wisconsin Rapids) |
EDTA Pink Top Tube (PTT) | EDTA Lavender Top Tube (LTT) | 1.0 mL Plasma | 0.5 mL Plasma | 0.3 mL Plasma |
| No |
Whole Blood
(Performing Sites - Weston and |
EDTA Pink Top Tube (PTT) | EDTA Lavender Top Tube (LTT) | 1.0 mL Whole Blood | 0.5 mL Whole Blood | 0.3 mL Whole Blood |
Collection/Processing Instructions
Marshfield Center Lab: Plasma must be separated from red cells within 7 hours of collection. If assay cannot not be performed within 7 hours, plasma may be stored up to 24 hours refrigerated, or at -20° Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25° C may be used to obtain the plasma sample.
Regional Center Labs: Whole blood must be analyzed within 7 hours of collection. If assay cannot not be performed within 7 hours of collection, then centrifuge and remove plasma within 7 hours of collection, and send to Marshfield Center lab for testing. Plasma may be stored up to 24 hours refrigerated, or at -20° Celsius for longer storage. Preferred storage is frozen. For add-on (U-have) testing, EDTA whole blood samples (pink or lavender top tube) stored up to 7 hours at 2-25° C may be used to obtain the plasma sample.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| EDTA Whole Blood | Ambient | 7 hours |
| Refrigerate | 7 hours | |
| EDTA Plasma | Ambient | 7 hours |
| Refrigerate | 24 hours | |
| Frozen at -20 deg Celsius | > 24 hours (up to 3 months) |
Rejection Criteria
| Whole Blood > 7 hours |
| Room Temperature Plasma > 7 hours |
| Refrigerated Plasma > 24 hours |
Interferences
Hemolyzed specimens should be avoided whenever possible. However, hemoglobin (up to 500 mg/dL), triglycerides (triolein up to 3000 mg/dL), bilirubin (up to 20 mg/dL) or human serum albumin (up to 1500 mg/L) do not interfere with the recovery of BNP per Biosite literature.
Interpretations
Normal values < = 100 pg/mL
BNP results greater than 100 pg/mL are considered abnormal and suggestive of patients with CHF.
The following interpretative comment is added to all results:
>100 to <200 pg/mL: Likely compensated congestive heart failure (CHF)
200 to 400 pg/mL: Likely moderate CHF
>400 pg/mL: Likely moderate to severe CHF
Reference Range Information
All Performing sites ≤100 pg/mL
Marshfield Labs Performing Department
Marshfield Labs Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Eau Claire | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Park Falls | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Ladysmith Medical Center | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Marshfield | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman DXI |
| Minocqua | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Neillsville | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Rice Lake | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Stevens Point | Monday through Sunday | Less than 2 hours | two-step immunoenzymatic assay/Beckman access2/DXI |
| Wisconsin Rapids | Monday through Sunday | Less than 2 hours | Fluorescence Immunoassay/Triage Meter Alere |
| Weston | Monday through Sunday | Less than 2 hours | Fluorescence Immunoassay/Triage Meter Alere |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83880 | 1 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83880 | 1 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | B-Type Natriuretic Peptide |