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Test Code BRSTSO Invitae Breast Cancer STAT Panel (50001)

Important Note

For internal ordering only. Not available to outreach clients.

Test is to be run STAT. Send out same-day as arrival to lab whenever possible (Monday-Friday).

Lab Processing: If requisition form does not arrive in lab within 1 day of receiving sample, reach out to ordering provider to obtain.

Ordering providers must send a completed test requisition form along with the specimen to lab, or fax to lab (715-221-6219).

Requisition forms available here:  Forms | Invitae

Additional Codes

Invitae Test Code: 50001

Useful For

All genes on this panel have published medical management guidelines and are associated with defined hereditary cancer syndromes.

 

This test is appropriate for breast cancer patients with upcoming cancer-related breast surgeries and/or treatment where genetic testing may inform decisions such as lumpectomy versus mastectomy, single versus double mastectomy, or use of other treatments (such as use of PARP inhibitors or other chemotherapy regimens). Identification of a disease-causing variant may also guide testing and management of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

Specimen Requirements

Submit one of the following specimens:       
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No Whole Blood EDTA Lavender Top Tube (LTT)   3 mL   1.5 mL
No Saliva Oragene self collection kit   2 mL for OG500/OGD500 and 1 mL for OGD510    

Collection/Processing Instructions

Blood should be shipped overnight at room temperature. 

 

Store saliva at room temperature, avoiding lengthy refrigeration. Although there are no special time requirements, we recommend that the specimen be mailed to Invitae soon after collection.

 

Saliva collected and stored in an OrageneTM self collection kit (OG500/OGD500/OGD510)

 

  • Please note that this kit requires 2 mL of saliva for OG500/OGD500 and 1 mL of saliva for OGD510, and involves active (not assisted) saliva donation.

Specimen Stability Information

Specimen Type Temperature Time
Saliva Ambient No special requirements
Whole Blood Ambient 48 hours
Refrigerated 14 days

Rejection Criteria

Hemolyzed, clotted, or frozen blood
Blood or saliva from patients who have had an allogeneic (non-self donor) bone marrow transplant
Blood or saliva from patients who have had an allogeneic (non-self donor) stem cell transplant
Blood or saliva from patients who had a blood transfusion less than two weeks prior to specimen collection
Saliva in any other container other than Oragene kits
Assisted saliva and gDNA are not accepted

Test Information

The Invitae Breast Cancer STAT Panel includes up to 9 well-established genes that are associated with a significantly increased risk of developing breast cancer. Accelerated turnaround time (TAT) is needed because physicians and patients often want to make surgical and management decisions as quickly as possible. Individuals who are identified with an inherited pathogenic variant have a higher risk of developing another breast cancer and may choose more aggressive surgery and/or different treatment options based on genetic testing results.

 

All genes on this panel have published medical management guidelines and are associated with defined hereditary cancer syndromes.

 

This test is appropriate for breast cancer patients with upcoming cancer-related breast surgeries and/or treatment where genetic testing may inform decisions such as lumpectomy versus mastectomy, single versus double mastectomy, or use of other treatments (such as use of PARP inhibitors or other chemotherapy regimens). Identification of a disease-causing variant may also guide testing and management of at-risk relatives. This test is specifically designed for heritable germline mutations and is not appropriate for the detection of somatic mutations in tumor tissue.

Interpretations

An interpretive report will be provided

Reference Range Information

An interpretive report will be provided

Performing Laboratory Name

Invitae

Referral Laboratory Information

Address Telephone Website Link
1400 16th Street

San Francisco, CA 94103

 800-436-3037

https://www.invitae.com

Performing Information

Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Invitae Monday through Saturday 5 to 12 days Next Generation Sequencing Deletion/Duplication Analysis

CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
81162   1 BRCA1, BRCA2 gene analysis; full sequenceanalysis and full duplication/deletion analysis  

Outreach CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
81162   1 BRCA1, BRCA2 gene analysis; full sequenceanalysis and full duplication/deletion analysis  

Ordering Applications

Ordering Application Description
COM Invitae Breast Cancer STAT Panel (#50001)
Cerner Invitae Breast Cancer STAT Panel (#50001)