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HelpTest Code CAT-RND Catecholamine/Creatinine Ratio, Urine (U CAT)
Synonyms/Keywords
Norepinephrine, Epinephrine, Dopamine, Adrenaline, U CAT
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Random Urine | Sage Cup with 0.1g sulfamic acid | 50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5 | 10 mL | 5 mL | 3 mL |
Collection/Processing Instructions
Urine must be preserved immediately at the time of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine (preserved) | Refrigerate | 1 week |
| Frozen | 1 week |
Rejection Criteria
Specimens that are unpreserved.
Test Components
Random Norepinephrine, Epinephrine, Dopamine, Creatinine
Test Information
Cautions:
- Patient results determined by other methods may not be comparable.
- Many alterations in physiologic and pathologic states can profoundly affect catecholamine concentrations, as well as a variety of substances and drugs.
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Interferences
Levodopa, Carbidopa, L-Dopa, Aldomet, Methenamine Mandelate, Buspirone
Interpretations
Catecholamines can be excreted into the urine in large amounts in patients with tumors of chromaffin tissue: pheochromocytoma, paraganglioma and neuroblastomas. Approximately 90% of all pheochromocytomas originate in the adrenal medulla and are characterized by an increased excretion of epinephrine. Extra adrenal pheochromocytomas (paragangliomas) mainly secrete norepinephrine and can develop anywhere along the course of the sympathetic chain from the neck to the pelvis. Children are more prone to develop a paraganglioma than are adults. Elevated catecholamine levels can also be seen with tumors of neural origin: neuroblastomas and gangliomas.
Reference Range Information
Norepinephine
<1 year: 0.025-0.310 ug/mg creatinine
1-3 years: 0-025-0.290 ug/mg creatinine
4-9 years: 0.027-0.108 ug/mg creatinine
10-17 years: 0.004-0.105 ug/mg creatinine
≥18 years: 0.009-0.112 ug/mg creatinine
Epinephrine
<1 year: 0.000-0.375 ug/mg creatinine
1-3 years: 0.000-0.082 ug/mg creatinine
4-9 years: 0.005-0.093 ug/mg creatinine
10-17 years: 0.003-0.058 ug/mg creatinine
≥18 years: 0.001-0.044 ug/mg creatinine
Dopamine
<1 year: 0.24-1.29 ug/mg creatinine
1-3 years: 0.08-1.22 ug/mg creatinine
4-9 years: 0.22-0.72 ug/mg creatinine
10-17 years: 0.12-0.45 ug/mg creatinine
≥18 years: 0.03-0.35 ug/mg creatinine
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield |
Monday, Wednesday, Friday Samples must be in the performing department by 8am on the day of testing for results the same day |
1 day | UPLC-MS MS (Waters TQ-S system) |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82384 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82384 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Catecholamine/Creatinine Ratio, Urine |