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HelpTest Code CERULO Ceruloplasmin
Useful For
This test is useful for monitoring ceruloplasmin levels in blood. Decreased levels are primarily of interest in the diagnosis of Wilson's disease. Decreased levels are also seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired. Ceruloplasmin, and acute phase reactant, is increased in inflammatory disorders when estrogen levels are high, with malignant tumors, and acute leukemia.
Synonyms/Keywords
Copper Oxidase
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) | Serum Separator Tube (SST) | 0.5 mL | 0.4 mL | 0.3 mL |
Collection/Processing Instructions
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerate | 7 days |
| Frozen | 3 months |
Rejection Criteria
Plasma samples
Test Information
Oral contraceptives or estrogen will increase ceruloplasmin levels.
Interpretations
Decreased ceruloplasmin levels may be seen in primary biliary cirrhosis and in GI disorders where copper uptake is impaired. Decreased levels are primarily of interest in the diagnosis of Wilson’s Disease, also known as hepatolenticular degeration. This involves a defect in ceruloplasmin synthesis and results in excessive accumulation of copper in various body tissues – liver, cornea and brain tissue.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | 20-60 mg/dL |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday and Thursday | 6-8 hours | Turbidimetric method/The Binding Site Optilite analyzer |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82390 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82390 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Ceruloplasmin |
| COM | Ceruloplasmin |