Home
HelpTest Code CF97SO Cystic Fibrosis (CF), 97 variants (481025)
Additional Codes
LabCorp Test Code: 481025
Useful For
Determine affected or carrier status for 97 CF gene mutations. This assay may be used for individuals whose family history or ethnicity requires testing for less common mutations. Also available for routine screening of pregnant couples.
Discriminates between p.F508del and the following polymorphisms: F508C, I506V, and I507V p.F508C, p.I506V, and p.I507V.
Synonyms/Keywords
CF Carrier
CF Testing
481025
Specimen Requirements
| Specimen Type | Preferred Container/Tube |
Acceptable Container/Tube |
Specimen Volume |
|---|---|---|---|
| Whole blood |
EDTA Lavendar Top Tube (LTT); or yellow-top (ACD-A) tube |
EDTA Pink Top Tube (PTT) | 4 mL |
Collection/Processing Instructions
Maintain specimen at room temperature or refrigerate at 4°C
Special Instructions for Prenatal Testing: Integrated Genetics clients should call 800-848-4436 to speak to a laboratory genetic coordinator before collecting any specimens. In some circumstances, specimens from other family members may be required. All prenatal specimens (including cord blood) must be accompanied by a maternal blood specimen for maternal cell contamination studies.
Specimen Stability Information
Maintain specimen at room temperature or refrigerate.
Rejection Criteria
- Frozen specimen
- Hemolyzed specimen
- Quantity not sufficient for analysis
Improper container
Test Components
Testing for 97 cystic fibrosis mutations, including all of the mutations currently recommended by the ACMG and ACOG.
Interferences
False-positive results or false-negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, erroneous representation of family relationships, or contamination of a fetal sample with maternal cells.
Interpretations
An interpretive report will be provided
Reference Range Information
An interpretive report will be provided
Performing Laboratory Name
LabCorp of America
Referral Laboratory Information
| Address | Telephone | Website Link | Marshfield Lab Account # |
|---|---|---|---|
|
6370 Wilcox Road Dublin, OH 43016 |
866-895-2291 | 48300485 |
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
|
Labcorp |
Sunday through Saturday | 7-10 days | DNA is isolated from the sample and tested for the 97 CF mutations listed. Regions of the CFTR gene are amplified enzymatically and subjected to a solution-phase multiplex allele-specific primer extension with subsequent hybridization to a bead array and fluorescence detection. Some mutations are then specifically identified by bidirectional dideoxysequencing. |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 81220 | 1 | CFTR gene analysis; common variants |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 81220 | 1 | CFTR gene analysis; common variants |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Cystic Fibrosis (CF), 97 variants (481025) |