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HelpTest Code CO-CAN Cannabinoids, Urine, Confirm Only by LCMS
Useful For
Detecting abuse of marijuana
Synonyms/Keywords
CBD, Marijuana, THC, Tetrahydrocannabinol
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Urine | Sage urine collection container | Sterile plastic container with no preservatives | 7 mL | 5 mL | 3 mL |
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerate (Preferred) | 30 days |
| Ambient | 72 hours |
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Marijuana is composed of more than sixty C21 compounds found in the leaves and flowering tops of the plant Cannabis sativa L. These compounds and their metabolites, collectively called cannabinoids, are excreted in the urine of marijuana users. This test is a confirm-only test for two cannabinoids in urine:
1. THCA (or 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid) is the primary metabolite of the psychoactive drug THC found in marijuana and comprises about one third to one half of the cannabinoids found in urine.
2. CBD (or cannabidiol) is a cannabinoid also found in marijuana, and has seen a recent surge in over-the-counter supplements that fall into the fringe of legality. Unlike THC, it has no known psychoactive properties. Currently, the only FDA-approved medical use for CBD is treatment of refractory epilepsy.
This LC-MS/MS confirmation-only test is intended for use only in patients where an initial drug screening test has already been performed at the time of specimen collection (i.e. point-of-care drug screening cup, dipstick, etc.). The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LC-MS/MS.
Interpretations
Current Cutoff Levels for Toxicology
The marijuana metabolite is retained in adipose tissue, and has a widely variable detection time. In general, single-use can be detected up to 3 days afterward; chronic heavy use can be detected 21-30 days after the last use.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | ALL: Negative. Positives are reported with a quantitative LC-MS/MS result. |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 2-4 days | Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80349 | 1 | Cannabinoids Confirmation by LC/MS/MS | ||
| G0480 | 1 | Cannabinoids Confirmation by LC/MS/MS | For Marshfield Clinic and Medicare/Medicaid |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80349 | 1 | Cannabinoids Confirmation by LC/MS/MS | ||
| G0480 | 1 | Cannabinoids Confirmation by LC/MS/MS | For Medicare/Medicaid |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Cannabinoid, Urine, Confirm Only by LCMSMS |
| COM | Cannabinoids, Urine, Confirm |