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HelpTest Code CO-OXY Oxycodone, Urine, Confirm Only by LCMSMS
Useful For
Detecting exposure to oxycodone and/or oxmorphone to monitor compliance in taking prescribed medications or to detect abuse.
Synonyms/Keywords
Oxycodone, Oxymorphone, Oxycontin, Percodan, Percocet, Opana
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Urine | Sage urine collection container | Sterile plastic container with no preservatives | 2 mL | 1 mL | 0.5 mL |
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Ambient | 72 hours |
| Refrigerate (Preferred) | 30 days |
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
This test is an LCMS/MS confirmation only for oxycodone and oxymorphone. It is intended for use only in patients where an intial drug screening test has already been performed at the time of specimen collection (i.e. Point-of-Care drug screening cup, dipstick, etc.) The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LCMS/MS.
Oxycodone and oxymorphone are opiods (semisynthetic narcotic analgesics derived from the compound thebane which occurs naturally in opium). Oxycodone is available in many preparations for oral use including Percodan, Percocet, and Oxycontin. Oxycodone is partially metabolized in the body to oxymorphone. Oxymorphone is also available in an oral preparation to treat chronic pain.
Interpretations
1. Oxycodone metabolizes to oxymorphone.
2. Hydrocodone can be a pharmaceutical impurity of the Oxycodone production process. It may be present in very small amounts with high levels of Oxycodone (less than 4% of the oxycodone level).
3. Oxycodone and Hydromorphone can be pharmaceutical impurities of the Oxymorphone production process. If either are present at levels less than or equal to 0.5% of the Oxymorphone level, it is likely an impurity and not evidence of use of Oxycodone and/or Hydromorphone.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Negative. Positives are reported with a quantitative LCMS/MS result. |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 2-4 days | Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80365 | 1 | Oxycodone Confirmation by LC/MS/MS | ||
| G0480 | 1 | Oxycodone Confirmation by LC/MS/MS | For Marshfield Clinic and Medicare/Medicaid |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80365 | 1 | Oxycodone Confirmation by LC/MS/MS | ||
| G0480 | 1 | Oxycodone Confirmation by LC/MS/MS | For Medicare/Medicaid |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Oxycodone, Urine, Confirm Only by LCMSMS |
| COM | Oxycodone, Urine, Confirm |