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HelpTest Code CULVRSO Copper, Liver Tissue
Additional Codes
Mayo Test Code: CUT
Reporting Name
Copper, Liver TsUseful For
Diagnosing Wilson disease and primary biliary cirrhosis using liver tissue specimens
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Liver TissueSpecimen Required
Supplies: Metal Free Specimen Vial (T173)
Container/Tube:
Preferred: Mayo metal-free specimen vial
Acceptable: Paraffin block, with no more than 1 or 2 cuts previously made
Specimen Volume: 2 mg
Collection Instructions: Two mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.
Specimen Stability Information:
Fresh or formalin-fixed liver tissue specimens: Frozen (-30 to -10° C) at least 20 years
Paraffin-embedded (block) liver tissue specimens: Ambient (16 to 24° C) at least 12 1/2 years
Additional Information: Paraffin blocks will be returned 7 days after analysis is complete.
Specimen Minimum Volume
Needle biopsy: See Specimen Required; 2 mm x 2 mm (punch): 0.3 mg by dry weight
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Liver Tissue | Refrigerated (preferred) | |
| Ambient | ||
| Frozen | ||
Reference Values
<50 mcg/g dry weight
Day(s) Performed
Monday, Thursday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82525
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CUT | Copper, Liver Ts | 8198-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8687 | Copper, Liver Ts | 8198-4 |
Cautions
Specimen handling should be minimized.
Elevated copper levels without supporting histology or other biochemical test results should instigate an investigation into whether the specimen has been contaminated.
A minimum tissue dry weight of 0.3 mg is required for analysis. This is the equivalent of a piece of tissue from a 22-gauge needle approximately 0.5 cm long, or approximately 0.3 cm in length when taken with an 18-gauge needle. Since the specimen must be manipulated during analysis, more than the minimal amount described in the previous sentence must be submitted for analysis.
Paraffin blocks that have been cut for slides may be contaminated if the microtome was previously used to cut specimens that had been fixed with a copper-containing solution. Many fixatives, such as Hollande's, contain high levels of copper. Any object that has been exposed to these fixatives (eg, cutting boards, towels, containers, utensils) and then comes into contact with the tissue can potentially contaminate the specimen. Rinsing and washing will not remove the copper contaminant. Therefore, submission of fresh-frozen, unfixed tissue is strongly recommended.
Report Available
3 to 6 daysSpecimen Retention Time
60 daysReject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Method Name
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Forms
If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Test Request (T728) with the specimen.