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HelpTest Code DHEASO4 Dehydroepiandrosterone Sulfate (DHEA-SO4)
Useful For
This test is useful in the diagnosis of congenital adrenal hyperplasia and adrenal carcinoma and determining the cause of hirsutism, virilization, and polycystic ovary disease.
Synonyms/Keywords
DHEA-SO4
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) | Serum Separator Tube (SST) | 1.0 mL | 0.5 mL | 0.3 mL |
Collection/Processing Instructions
Samples collected in a RTT must be removed from the clot within one hour for storage or transport.
Samples collected in gel barrier tubes must be removed from the primary tube prior to transporting to Marshfield. Do not send the primary collection tube.
DHEASO4 is not the same test as DHEA (See Test Information).
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated | 2 days |
| Frozen | 2 months |
Rejection Criteria
Grosssly lipemic
Test Information
DHEA-SO4 has little androgenic activity but is the precursor for peripheral conversion to the active androgens following the metabolic pathway of DHEA, androstenedione, testosterone, and dihydrotestosterone, with increasing androgenic potency in that order. Measurement of DHEA-SO4 is to determine the adrenal source of androgen. Excessive adrenal secretion of the androgen precursor has a noticeable clinical consequence. Clinical manifestations include hirsutism, virilization, and polycystic ovary disease.
The drug asfotase alfa (STRENSIQ), a recombinant form of alkaline phosphatase, is expected to interfere with in vitro diagnostic assays utilizing an alkaline phosphatase detection system. Test samples from patients taking asfotase alfa with a non-alkaline phosphatase methodology.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
Male (ug/dL) Female (ug/dL) 0-1 month: 9-316 15-261 1-6 months: 3-58 0-74 7-36 months: 0-26 0-26 4-6 years: 0-34 0-34 7-9 years: 0-74 0-74 10-12 years: 3-137 3-137 13-18 years: 3-237 3-237 19-29 years: 140-640 65-380 30-49 years: 95-530 32-270 ≥50 years: 40-310 <30-200
Pediatric reference ranges taken from: Soldin, S.J. et.al., "Pediatric Reference Ranges for DHEA Sulfate" |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 1 day | DPC Immulite Chemiluminescent EIA |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82627 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82627 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Dehydroepiandrosterone Sulfate (DHEA-SO4) |