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Test Code DSDNA Double Stranded DNA Antibodies

Useful For

DsDNA antibodies are characteristic markers in Systemic Lupus Erythematosus (SLE). This antibody is found in 60-70% of SLE patients. Low levels of dsDNA have been indicated in rheumatic disease patients and as a precursor to disease recognition.



See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy. 

Synonyms/Keywords

Anti-DNA, DNA antibodies, native DNA

Specimen Requirements

Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No Serum Red Top Tube (RTT) or Serum Separator Tube (SST)   1.0 mL 0.4 mL 0.3 mL

Collection/Processing Instructions

Separate serum from cells within 2 hours of collection.

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerate 7 days
Frozen > 7 days

Rejection Criteria

Gross hemolysis
Gross lipemia

Interpretations

A positive result supports the diagnosis of systemic lupus erythematosus.

Reference Range Information

Performing Location Reference Range
Marshfield

≤4 IU/mL: Negative

5 - 9 IU/mL: Indeterminate

≥10 IU/mL: Positive

Analytical measuring range is 1 -300 IU/mL

Marshfield Labs Performing Department

Marshfield Labs Immunodiagnostics

Performing Information

Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield Monday through Friday 1 day Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200

CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
86225        

Outreach CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
86225        

Ordering Applications

Ordering Application Description
Centricity Double Stranded DNA Abs
Cerner DNA Antibody (Double-stranded) IgG