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Test Code FELVRSO Iron, Liver Tissue

Additional Codes

Mayo Test Code: FET

Reporting Name

Iron, Liver Ts

Useful For

Diagnosis of hemochromatosis using liver tissue specimens

Testing Algorithm

For more information see Hereditary Hemochromatosis Algorithm.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Liver Tissue


Necessary Information


Patient's date of birth is required to calculate iron index.



Specimen Required


Supplies: Metal Free Specimen Vial (T173)

Container/Tube:

Preferred: Mayo metal-free specimen vial

Acceptable: Paraffin block, with no more than 1 or 2 cuts previously made

Specimen Volume: 2 mg

Collection Instructions: Two mg of liver tissue are required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.

Specimen Stability Information:

Fresh or formalin-fixed liver tissue specimens: Frozen (-30 to -10° C) at least 20 years

Paraffin-embedded (block) liver tissue specimens: Ambient (16 to 24° C) at least 12 1/2 years

Additional Information: Paraffin blocks will be returned 7 days after analysis is complete.


Specimen Minimum Volume

Needle biopsy: See Specimen Required; 2 mm x 2 mm (punch): 0.3 mg by dry weight

Specimen Stability Information

Specimen Type Temperature Time
Liver Tissue Refrigerated (preferred)
  Ambient 
  Frozen 

Reference Values

Iron

Males: 200-2,400 mcg/g dry weight

Females: 200-1,800 mcg/g dry weight

 

Iron Index

≥13 years: <1.0 mcmol/g/year

Reference values have not been established for patients that are younger than 13 years.

Day(s) Performed

Monday, Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83540

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FET Iron, Liver Ts 57028-3

 

Result ID Test Result Name Result LOINC Value
8350 Iron, Liver Ts 57028-3
7770 Hepatic Iron Index 49061-5

Cautions

Formalin-fixed, paraffin-embedded tissue can be used when histologic examination (including iron stains) is requested in addition to the hepatic iron concentration and calculated hepatic iron index; however, fresh or frozen tissue is preferred.

 

Paraffin blocks from which many slides have been previously cut often appear to contain sufficient quantity of tissue, however, the specimen is often very thin and less than 2 mg in weight.

Report Available

3 to 6 days

Specimen Retention Time

60 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)