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HelpTest Code FVL Factor 5 (V) Leiden
Useful For
People with Factor V Leiden (G1691A) mutations have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT). Factor V Leiden mutation tests are ordered when it is suspected that a person has an inherited risk factor for thrombosis, for example, in someone who has a first DVT or venous thromboembolism (VTE) before age 50 or in an unusual part of the body.Synonyms/Keywords
Factor V Leiden Mutation Test, FV R506Q, Hypercoagulability, ThrombophiliaSpecimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Whole Blood | EDTA Lavender Top Tube (LTT) | Citrated Blue Top Tube (BTT) | 3.0 mL | 1.0 mL |
Collection/Processing Instructions
Tube must be drawn at least 90% full. Invert tube completely three or four times to mix. Do not shake. Do not open tube. Note: The blood specimen tube must not be opened prior to analysis.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood | Room Temperature | < 24 hrs |
| Refrigerate | ≤ 15 days | |
| Frozen | ≤ 3 months |
Rejection Criteria
| Clotted |
|---|
| Tubes that have been opened or previously processed |
| Unacceptable temperature storage |
| Heparinized blood |
Interpretations
Heterozygous for Factor V Leiden: the relative risk of venous thrombosis is about 4 to 5-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.
Homozygous for Factor V Leiden: the relative risk of venous thrombosis is between 10 to 70-fold that of the general population. Other conditions, either acquired or inherited, may act synergistically to increase an individual's thrombotic risk.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Heterozygous, Homozygous, or Normal (No evidence of FV Leiden or PTG mutation). |
Marshfield Labs Performing Department
Marshfield Labs Molecular Pathology
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 6-8 hours | PCR/Genetic mutation |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 81241 | Factor V Leiden | |||
| DEX Z-Code | ZB4IL |
|||
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 81241 | Factor V Leiden |
|
||
| DEX Z-Code |
ZB4IL |
|||
Ordering Applications
| Ordering Application | Description |
|---|---|
| Centricity |
Factor 5 (V) Leiden Profile or Factor-V Leiden |
| Cerner | Factor V Leiden |
| COM | Factor 5 (V) Leiden |