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HelpTest Code HEPUF Heparin, Unfractionated
Useful For
Monitoring unfractionated heparin therapy.
If monitoring low molecular weight heparin (Lovenox, etc), then order Heparin, Low Molecular Weight (HEPLMW).
If monitoring fondaparinux (Arixtra), then order LabCorp test code 500465 (Fondaparinux Anti-Xa) as a "MISC" test.
Synonyms/Keywords
Heparin-unfract, Unfractionated Heparin, Xa, Anti-Xa
Specimen Requirements
| Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|
| *Platelet Poor Plasma | 3.2% Citrated Blue Top Tube (BTT) | 0.75 mL | 0.75 mL | 0.5 mL |
Collection/Processing Instructions
One 0.75 mL citrated Blue Top Tube (BTT) plasma aliquot. (If more than one coagulation test is ordered, a separate aliquot is needed for each test.)
- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%
- Tube must be at least 90% full
- Invert completely 3-4 times (without shaking) to mix
*See Instructions for: Preparation of Platelet Poor Plasma
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma (stored on cells or platelet poor aliquot) | Room Temperature (15 to 25° C) | 4 hours |
| Platelet Poor Plasma | Frozen (≤ -18° C) | 3 days |
| Platelet Poor Plasma | Frozen (≤ -74° C) | 3 months |
Rejection Criteria
| Specimen tubes under-filled (below the fill line) and over-filled (above the fill line) |
|---|
| Gross Hemolysis |
| Clotted |
| Frozen whole blood |
| Contamination with IV or Hickman Line fluids |
| Specimens that thaw during storage or transport |
| Specimens with HCT >55% that have not had the citrate anticoagulant adjusted |
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
When measured by the anti-Xa method, the recommended therapeutic range for unfractionated heparin is 0.30-0.70 IU/mL. (Chest 2008; 133(6S):141S-159S) See Critical Value Policy for list of current critical values |
Marshfield Labs Performing Department
Marshfield Labs Hematology
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday 8 am - 4 pm |
Less than 2 hours | Anti-Factor-Xa Chromogenic/Siemens Sysmex CS 2500 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 85520 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 85520 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Heparin, Unfractionated |