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HelpTest Code HPVGENO HPV-Human Papillomavirus Genotyping 16, 18/45(NAM)
Useful For
HPV Genotyping should only be ordered on samples that have tested positive for high risk HPV. The currently recommended indication for HPV genotyping is in cases when a woman has had a normal cervical cytology result in conjunction with a HR-HPV positive result. If HPV genotyping reveals the presence of HPV 16 or 18/45 the patient should be referred to colposcopy. If HPV genotyping does not reveal HPV 16 or 18/45 the patient should have cytology and HR-HPV testing performed again in 12 months.
Synonyms/Keywords
HPV, ThinPrep, Genotyping
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Cervical/Vaginal spatula/cytobrush | ThinPrep Vial | Green Label Aptima Tube | 1 mL | 1 mL |
Acceptable Body Sites
Default: CERVICAL-VAGINAL
Allowed: CERVICAL-VAGINAL, CERVIX, CERVIX-ENOCERVIX, ENDOCERVICAL, ENDOMETRIUM, LATERAL WALL, OTHER, VAGINAL, VAGINAL CUFF, VAGINAL VAULT, VULVA
Acceptable Specimen Types
Cervical/Vaginal ThinPrep
Collection/Processing Instructions
Cervical specimens obtained using a spatula/cytobrush collection device and placed in ThinPrep vial containing PreservCyt solution. Transport ThinPrep specimen at room temperature overnight.
Samples submitted in green label Aptima tubes containing 1.0 mL of PreservCyt solution will be accepted if the sample previously tested positive for High Risk HPV.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| ThinPrep | Ambient | 30 days |
| Aptima Specimen | Ambient | 60 days |
Rejection Criteria
|
Insufficient amount (less than 1 mL) |
|---|
| Samples in Sure Path collection vials |
Test Information
HPV Genotyping should only be ordered on samples that have tested positive for high risk HPV. If Marshfield Labs performed the HPV nucleic acid testing within the last 20 days, please call the Molecular Pathology lab section at 715-221-6191 to have the HPV sample retrieved for this testing request. Marshfield Labs Molecular Pathology section is staffed Monday Friday (0400-1700). If there is no answer at this phone number, please leave your name and contact phone number so staff can contact you for patient order information.
Interpretations
Reported as Negative, Positive or Indeterminate for HPV Genotype 16, 18/45 in cervical specimens by TMA.
Reference Range Information
See Report
Marshfield Labs Performing Department
Marshfield Labs Molecular Pathology
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Wednesday | 6-8 hours* | Transcription-Mediated Amplification (TMA) |
| *Testing performed once/week. Sample must be received in the lab by 0400 Wednesday to be tested same day. | |||
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 87625 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 87625 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Clinical Order Manager | HPV Genotyping 16, 18/45 (NAM) |