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HelpTest Code IGG-CSF CSF IgG
Useful For
Measurement of the CSF, albumin and IgG, are directed mainly towards the demonstration of two common disorders, namely blood-brain barrier damage and selective elevation of IgG due to local synthesis within the CNS.
Synonyms/Keywords
Immunoglobulin G in spinal fluid; Immunoglobulin G, CSF
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) | Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Spinal Fluid (CSF) | Spinal fluid collection tube | Plastic tube | 1.0 mL | 0.5 mL | 0.5 mL |
Collection/Processing Instructions
Collection must be made with no red blood cells (RBC)
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| CSF | Refrigerated | 7 days |
Rejection Criteria
| Hemolysis and/or the presence of intact RBCs in the CSF specimen |
|---|
| Frozen samples |
Test Components
CSF IgG, CSF Albumin
Test Information
Hemolysis and/or the presence of intact RBCs in the CSF specimen will elevate both the CSF albumin and IgG because of serum contamination.
Interpretations
An increase in the CSF IgG with a corresponding increase in the CSF IgG/Albumin Ratio suggests that the IgG is produced locally. Increases of IgG without corresponding increases in the ratio indicate damage to the blood-brain barrier. In rare instances, the CSF albumin can be elevated and the IgG normal. This can mean the blood-brain barrier has become permeable to albumin, but not IgG, which is a larger molecule. Guillian-Barre Syndrome, which has been associated with influenza immunization shots, will give similar results. The total protein will also be elevated in this syndrome. The difference here is that the albumin is derived from breakdown of the CNS tissues.
Reference Range Information
| Performing Location | Reference Range |
|
Marshfield |
|
| IgG (CSF): 0-6.6 mg/dL | |
| Albumin (CSF): 15-32 mg/dL | |
| IgG/Albumin ratio: 0.00-0.27 |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 6-8 hours | Turbidimetric method/The Binding Site Optilite analyzer |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82784 | ||||
| 82042 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82784 | ||||
| 82042 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | IGG-CSF |