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HelpTest Code LAMO Lamotrigine
Useful For
Monitoring lamotrigine. Lamotrigine is an anticonvulsant drugs used for the treatment of epilepsy. In addition to its anticonvulsant properties, it is approved for the maintenance treatment of bipolar type 1 disorder.
Synonyms/Keywords
Lamictal
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No |
Serum |
Red Top Tube (RTT) | 0.5 mL | 0.5 mL | 0.3 mL |
Collection/Processing Instructions
Indicate collection time.
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Ambient | 48 hrs |
| Refrigerate | 2 weeks | |
| Frozen | 2 weeks |
Rejection Criteria
Specimens collected in a gel-barrier collection tube
Heparinized or EDTA plasma
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Interpretations
With monotherapy, lamotrigine has relatively few side-effects and generally doesn't lead to toxicity. However, clearance is altered by several other compounds and combination therapy with other anticonvulsant drugs can have a substantial effect on the clearance of this drug. Possible toxicity may be observed at concentrations of ≥ 20 ug/mL.
Trough concentrations are most accurate and recommended for therapeutic drug monitoring. Preferably obtained just before the next dose.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
No reference range is established for lamotrigine Minimum trough levels of 1-3 ug/mL are required for efficacy Levels as high as ≥ 10 ug/mL are used clinically. Possible toxicity at levels ≥ 20 ug/mL Optimal dosing cannot be currently established based on blood levels |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday, Wednesday, Friday | 1 day | UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System |
| Samples must be in performing department by 8am on day of testing for results the same day. Testing may be batched and set up on alternative days of the week as needed. | |||
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80175 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80175 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| COM | Lamotrigine |
| Cerner | Lamotrigine Level |