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HelpTest Code MMA Methylmalonic Acid
Useful For
Methylmalonic acid (MMA) is a metabolite that accumulates when vitamin B12 (cobalamin) is unavailable as a cofactor for converting methylmalonyl-CoA to succinyl-CoA. Measurement of MMA is helpful as a confirmatory test for patients with borderline low serum vitamin B12 levels. A normal MMA result rules out B12 deficiency states.
Synonyms/Keywords
Methylmalonic acid quantitative - serum, MMA
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) | Serum Separator Tube (SST) | 250 uL | 200 uL |
Collection/Processing Instructions
Separate serum/plasma from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerate | 1 week |
| Freeze | 1 year |
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | ≤ 0.40 umol/L |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Thursday | 6-8 hours | UPLC MS/MS (Waters TQ-XS LC Tandem Mass Spectrometry system) |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83921 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83921 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| COM | Methylmalonic AC(MMA),Qnt.Serum |
| Cerner | Methylmalonic Acid Level |