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HelpTest Code NASHFSO NASH FibroSure® Plus (550960)
Additional Codes
LabCorp Test Code: 550960
Useful For
This test is a noninvasive assessment of liver status in patients with nonalcoholic fatty liver disease (NAFLD). Quantitative results of 10 biochemicals in combination with age and gender are analyzed using a computational algorithm to provide a quantitative surrogate marker (0.0-1.0) of liver fibrosis (Metavir F0-F4), hepatic steatosis (0.0-1.0, S0-S3), and nonalcoholic steatohepatitis (NASH) (0.0-0.75, N0-N2). The absence of steatosis (S<0.41) precludes the diagnosis of NASH.
Synonyms/Keywords
Fatty Liver Disease, NAFLD, Nonalcoholic Fatty Liver Disease, Noninvasive Liver Biopsy, Steatohepatitis
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| Minimum of 8 hours | Serum |
Serum Separator Tube (SST) |
Red Top Tube (RTT) | 3.5 mL | 2 mL |
Collection/Processing Instructions
Patient Preparation: Patient should be fasting for at least eight hours.
The patient's age and gender must be submitted, but the patient's height and weight are NOT required for NASH FibroSure Plus testing.
Separate serum from cells within two hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
|
Serum |
Ambient | 72 hours |
| Refrigerated at 2°C to 8°C | 72 hours | |
| Frozen at -70°C (preferred) | 7 days | |
| Freeze/thaw cycles | Stable x1 |
Rejection Criteria
| Gross hemolysis |
| Gross lipemia |
| Improper labeling |
| Nonfasting specimen |
| Patient younger than 14 years of age |
Test Components
a2-macroglobulin, haptoglobin, apolipoprotein A1, bilirubin, y-glutamyl transpeptidase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, triglycerides, and fasting glucose
Test Information
This test is a noninvasive assessment of liver status in patients with nonalcoholic fatty liver disease (NAFLD). Quantitative results of 10 biochemicals in combination with age and gender are analyzed using a computational algorithm to provide a quantitative surrogate marker (0.0-1.0) of liver fibrosis (Metavir F0-F4), hepatic steatosis (0.0-1.0, S0-S3), and nonalcoholic steatohepatitis (NASH) (0.0-0.75, N0-N2). The absence of steatosis (S<0.41) precludes the diagnosis of NASH.
Interferences
NASH FibroSure Plus is recommended for patients with suspected nonalcoholic fatty liver disease. It is not recommended for patients with other liver diseases. It is also not recommended in patients with Gilbert disease, acute hemolysis, acute viral hepatitis, drug induced hepatitis, genetic liver disease, autoimmune hepatitis and/or extra- hepatic cholestasis. Any of these clinical situations may lead to inaccurate quantitative predictions of fibrosis.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| LabCorp of America | Interpretive report |
Performing Laboratory Name
LabCorp of America
Referral Laboratory Information
| Address | Telephone | Website Link | Marshfield Lab Account # |
|---|---|---|---|
|
6370 Wilcox Road Dublin, OH 43016-1296 |
800-282-7300 | www.labcorp.com | 48300485 |
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| LabCorp of America | Testing schedule may vary. | 4 to 6 days | Quantitative results of 10 biochemicals incombination with age and gender are analyzed using a computational algorithm toprovide a quantitative surrogate marker (0.0-1.0) of liver fibrosis (MetavirF0-F4), hepatic steatosis (0.0-1.0, S0-S3), and nonalcoholic steatohepatitis(NASH) (0.0-0.75, N0-N2). The absence of steatosis (S<0.41) precludes thediagnosis of NASH. |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
|
83883 |
1 | Nephelometry | ||
| 83010 |
1 | Haptoglobin | ||
| 82172 |
1 | Apolipoprotein | ||
| 82247 |
1 | Bilirubin Total | ||
| 84460 |
1 | ALT | ||
| 82465 |
1 | Cholesterol | ||
| 84478 |
1 | Triglyceride | ||
| 82947 |
1 | Glucose | ||
| 84450 |
1 | AST | ||
| 82977 | 1 | GGT |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
|
83883 |
1 | Nephelometry | ||
| 83010 |
1 | Haptoglobin | ||
| 82172 |
1 | Apolipoprotein | ||
| 82247 |
1 | Bilirubin Total | ||
| 84460 |
1 | ALT | ||
| 82465 |
1 | Cholesterol | ||
| 84478 |
1 | Triglyceride | ||
| 82947 |
1 | Glucose | ||
| 84450 |
1 | AST | ||
| 82977 | 1 | GGT |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | NASH FibroSure Plus (550960) |