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HelpTest Code NMDARSO N-methyl-D-Aspartate Receptor Antibody, IgG, CSF with Reflex to Titer (2005164)
Additional Codes
ARUP Test Code: 2005164
Useful For
Confirm diagnosis of anti-NMDAR encephalitis.
May be used in monitoring treatment response in individuals who are antibody positive.
Synonyms/Keywords
anti-GluN1, Anti-NMDA CSF, anti-NR1, Glutamate Receptor Antibodies, N-Methyl D-Aspartate Ab CSF, NMDA R, NMDA Receptor Ab CSF
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | CSF | Sterile tube | 0.5 mL | 0.15 mL |
Collection/Processing Instructions
Transport refrigerated
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| CSF | Ambient | 48 hours |
| Refrigerated | 2 weeks | |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
Rejection Criteria
| Contaminated Specimens |
|---|
| Hemolyzed Specimens |
| Severely Lipemic Specimens |
Test Information
NMDA receptor antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response. In addition, positive results have been reported in patients with nonautoimmune phenotypes. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis. Results should be interpreted in correlation with the patients clinical history and other laboratory findings.
This indirect fluorescent antibody assay utilizes full-length GluN1 transfected cell lines for the detection and semiquantification of NMDA receptor IgG antibody.
Interpretations
If NMDA CSF antibody IgG is positive, then an NMDA CSF antibody IgG titer is reported. Additional charges apply.
Reference Range Information
Less than 1:1
Performing Laboratory Name
ARUP Laboratories
Referral Laboratory Information
| Address | Telephone | Website Link | Marshfield Lab Account # |
|---|---|---|---|
| ARUP Laboratories | 800-522-2787 | https://www.aruplab.com | 12057 |
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| ARUP | Sunday through Saturday | 1-3 days | Semi-Quantitative Indirect Fluorescent Antibody |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86255 | 1 | Fluorescent antibody screen | ||
| 86256 | 1 | Fluorescent antibody titer | If Reflexed |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86255 | 1 | Fluorescent antibody screen | ||
| 86256 | 1 | Fluorescent antibody titer | If Reflexed |