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HelpTest Code NT-proBNP N-terminal pro-Brain Natriuretic Peptide
Useful For
This test is used as an aid in the diagnosis of congestive heart failure.
Synonyms/Keywords
NT-proBNP
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Plasma/Serum | Lithium-heparin Plasma Separator Tube (PST) | Serum Separator Tube (SST), Red Top Tube (RTT) | 1.0 mL | 0.5 mL | 0.5 mL |
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
|
Serum/Plasma |
Ambient | 24 hours |
| Refrigerate | 3 days | |
| Frozen | 30 days |
Rejection Criteria
Specimens not stored as listed above
Test Components
Nt-proBNP
Interferences
Specimens that contain biotin at a concentraion of 250 ng/mL demonstrate a less than or equal to 10% change in results. Biotin concentrations greater than this may lead to falsely depressed results for patient samples. Results from patients taking biotin supplements or receiving high-dose biotin therapy should be interpreted with caution due to the possible interference with this test.
Interpretations
Marshfield:
Diagnostic Criteria:
Age-dependent rule-in cutoffs:
> = 450 ng/L for subjects < 50 years old
> = 900 ng/L for subjects 50-75 years old
> = 1800 ng/L for subjects > 75 years old
Age-independent rule-out cutoff: < 300 ng/L
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Males: <50: < = 84 pg/mL 50-75: < = 188 pg/mL >75: < = 243 pg/mL Females: < 50: < = 152 pg/mL 50-75: < = 282 pg/mL >75: < = 443 pg/mL |
Marshfield Labs Performing Department
Marshfield Labs Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Sunday through Saturday | 2 hours | Immunoenzymatic assay/ Beckman Coulter DXI 9000 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83880 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83880 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | N-terminal pro-Brain Natriuretic Peptide |