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Test Code PCHOTSO Pseudocholinesterase, Total, Serum

Additional Codes

Mayo Test Code: PCHE1


Necessary Information


Patient's age and sex are required.



Specimen Required


Patient Preparation: For patients with prolonged apnea following surgery, wait at least 24 hours before obtaining specimen.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.


Useful For

Monitoring exposure to organophosphorus insecticides and herbicides

 

Monitoring patients with liver disease, particularly those undergoing liver transplantation

 

Identifying patients who are homozygous or heterozygous for an atypical gene and have low levels of pseudocholinesterase

 

This test is not useful for the differential diagnosis of jaundice.

Method Name

Colorimetric Assay

Reporting Name

Pseudocholinesterase, Total, S

Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  365 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

Males

5320-12,920 U/L

 

Females

0-15 years: 5320-12,920 U/L

16-39 years: 4260-11,250 U/L

40-41 years: 5320-12,920 U/L

≥42 years: 5320-12,920 U/L

Note: Females aged 18-41 years who are pregnant or taking hormonal contraceptives, the reference interval is 3650-9120 U/L.

Cautions

There are some homozygous and heterozygous individuals who are sensitive to succinylcholine although their total pseudocholinesterase (PCHE) values are normal. A dibucaine inhibition test is necessary to confirm the presence of the abnormal allele in these individuals.

 

Certain drugs and anesthetic agents may produce in vitro inhibition of the PCHE activity. Therefore, it is recommended that blood specimens be drawn 24 to 48 hours post-operatively on those patients who have experienced prolonged apnea after surgery.

 

Chemotherapy may interfere with test results, depending on the impact it has on the liver. PCHE levels may be lower due to this, and if so, testing should be repeated at a later date.

 

Method Change: Pseudocholinesterase values measured after 01/28/2020 are approximately 80% increased compared to historical values and should be interpreted in the context of the current reference interval.

 

In very rare cases of gammopathy, particularly type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82480

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PCHE1 Pseudocholinesterase, Total, S 2098-2

 

Result ID Test Result Name Result LOINC Value
PCHE1 Pseudocholinesterase, Total, S 2098-2