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HelpTest Code RIBOP Ribosomal P Antibody
Useful For
A confirmatory test for the evaluation of patients with signs and symptoms of SLE associated with neuropsychiatric involvement. Ribosomal P antibodies may be detected by very dense fine granular cytoplasmic pattern by ANA IFA.
See the Mixed Connective Tissue Disease Panel Algorithm for suggested testing strategy.
Synonyms/Keywords
Ribosomal P, Anti-Ribosome P Antibodies,Ribosomal P Antibodies, Ribosome Antibody
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) or Serum Separator Tube (SST) | 1.0 mL | 0.4 mL | 0.3 mL |
Collection/Processing Instructions
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerate | 7 days |
| Frozen | > 7 days |
Rejection Criteria
| Gross lipemia |
|---|
| Gross hemolysis |
| Heat inactivated samples |
Test Information
Ribosomal P antibodies occur with active SLE (systemic lupus erythematosus), and are seen in association with CNS involvement and cardiolipin antibodies.
This tests aids in the differential diagnosis of neuropsychiatric symptoms in patients with SLE.
Since patients with SLE may manifest signs and symptoms of CNS diseases including neuropsychiatric symptoms, the presence of antibodies to ribosome P protein may be useful in the differential diagnosis of such patients. Other causes of CNS symptoms in patients with SLE include thrombosis with or without antibodies to phospholipid antigens and iatrogenic effects from treatment with corticosteroid drugs.
A positive result is consistent with the diagnosis of lupus erythematosus, and may indicate the presence of central nervous system involvement.
Interpretations
A positive results supports the diagnosis of SLE in the case of neuropsychiatric lupus.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
Negative: <1.0 Analytical measuring range 0.2 - 8.0 AI (Antibody Index) |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 1 day | Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86235 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86235 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Ribosomal P Antibody |