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HelpTest Code SYPHAB Syphilis, Antibody Screen, Routine
Useful For
This test is for screening/diagnostic purposes. For therapeutic monitoring order RPR, Therapeutic Monitoring (RPRTM).
Samples will be tested for IgG and IgM antibodies to Treponemal pallidum. Positive screens will reflex to the RPR (Rapid Plasma Reagin) test at an additional charge. In case the results of the IgG/IgM antibody testing disagree with the RPR, another treponemal test, Treponemal pallidum Particle Agglutination (TPPA) will be performed at an additional charge.
NOTE: The CDC and WHO recommend both a positive antibody test against the causative agent Treponema pallidum and a positive non-treponemal test such as the Rapid Plasma Reagin (RPR) before making a serological diagnosis of syphilis.
Synonyms/Keywords
Syphilis Screen, Treponema pallidum, VDRL, RPR
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) or Serum Separator Tube (SST) | 1.0 mL | 0.5 mL | 0.5 mL |
Collection/Processing Instructions
Separate serum from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerate | 7 days |
| Frozen | > 7 days |
Rejection Criteria
| Gross hemolysis |
| Gross icteric |
| Gross lipemic |
| Heat inactivated |
Test Components
Syphilis Treponemal - Total Antibody Screen
Rapid Plasma Reagin (RPR) (if needed)
Treponemal Particle agglutination (TPPA) ( if needed)
Interpretations
Link to: Syphilis Testing Algorithm
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Negative |
Marshfield Labs Performing Department
Marshfield Labs Immunodiagnostics
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 1 day | Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86780 | 1 | Syphilis,treponemal | ||
| 86593 | 1 | RPR (if needed) | ||
| 86780 | 1 | TP-PA (if needed) |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 86780 | 1 | Syphilis, treponemal | ||
| 86593 | 1 | RPR (if needed) | ||
| 86780 | 1 | TP-PA (if needed) |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Syphilis, Ab Screen, Routine |