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Test Code TDPU Targeted Drug Panel, Urine

Useful For

Qualitative, definitive urine drug test for the amines, benzodiazepines, and opioids drug classes.

Synonyms/Keywords

Drug screen, drug test, amines, amphetamine, methamphetamine, benzodiazepines, opiates, opioids

Specimen Requirements

Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No Urine Clean plastic container   5 mL 0.5 mL 0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerate (preferred) 30 days
Ambient 7 days

Test Components

Definitive/confirmatory panel to semi-quantitatively detect the use of amines/amphetamines, benzodiazepines, and opioids drug classes using Liquid Chromatography-Tandem Mass Spectrometry methodology. Quantitative results are not available, but drugs detected as present will be reported with a quantitative range in which it was detected.

 

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

 

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Test Information

This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.   

 

This assay is a semi-quantitative confirmatory test by liquid chromatography/tandem mass spectrometry (LC/MSMS). If an analyte or its corresponding metabolites are present in urine, it indicates that the patient has used the respective drugs recently. If a drug is detected, it will be reported as present, in three concentration ranges (low, moderate, and high) with the analytes specific ranges.

 

The test includes seven amines: amphetamine, methamphetamine, MDA, MDMA, MDEA, methylphenidate, ritalinic acid; six benzodiazepines: 7-aminoclonazepam, lorazepam, oxazepam, alphahydroxyalprazolam, nordiazepam, temazepam; seventeen opiates: buprenorphine, norbuprenorphine (buprenorphine metabolite), oxycodone, nor-oxycodone (oxycodone metabolite), oxymorphone (oxycodone metabolite), morphine, hydromorphone, 6-monoacetylmorphine (heroin metabolite), codeine, hydrocodone, gabapentin, tramadol, nor-tramadol (tramadol metabolite), fentanyl, nor-fentanyl (fentanyl metabolite), EDDP (methadone metabolite), and methadone. Analytes below the level of detection level will be reported as not detected.

 

This test was developed in-house with targeted analytes in consultation with pain management providers. The objective of this test is to provide useful information to help determine patient compliance or identify misuse of other drugs commonly present in our patient population.

 

Please see this document for a full list of drugs included in this panel, along with the detection levels of each: TDPU Test Components

 

NOTE: If other drug classes are also of interest (cannabinoids, cocaine, barbiturates, ethanol), it is recommended that the PCS4WO test be ordered along with this test.

Interpretations

Drugs are reported as Present or Not Detected. Drugs reported as Present are also reported as present at a Low, Moderate, or High level.

Reference Range Information

Performing Location Reference Range
Marshfield Noreference range for drugs found in urine. Presence of drug indicates ingestion/use only, and is not to be used fortherapeutic drug monitoring.

Marshfield Labs Performing Department

Marshfield Labs Special Chemistry

Performing Information

Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield Monday through Friday 2 days Waters TQ/XS Liquid Chromatography - Tandems Mass Spec system

CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
G0481   1 Drug test(s), definitive, utilizing (1) drugidentification methods able to identify individual drugs and distinguishbetween structural isomers (but not necessarily stereoisomers), including, butnot limited to GC/MS (any type, single or tandem) and LC/MS (any type, singleor tandem and excluding immunoassays (e.g., IA, EIA, ELISA, EMIT, FPIA) andenzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or otheruniversally recognized internal standards in all samples (e.g., to control formatrix effects, interferences and variations in signal strength), and (3)method or drug-specific calibration and matrix-matched quality control material(e.g., to control for instrument variations and mass spectral drift);qualitative or quantitative, all sources, includes specimen validity testing,per day; 8-14 drug class(es), including metabolite(s) if performed.  

Outreach CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
G0481   1 Drug test(s), definitive, utilizing (1) drugidentification methods able to identify individual drugs and distinguishbetween structural isomers (but not necessarily stereoisomers), including, butnot limited to GC/MS (any type, single or tandem) and LC/MS (any type, singleor tandem and excluding immunoassays (e.g., IA, EIA, ELISA, EMIT, FPIA) andenzymatic methods (e.g., alcohol dehydrogenase)), (2) stable isotope or otheruniversally recognized internal standards in all samples (e.g., to control formatrix effects, interferences and variations in signal strength), and (3)method or drug-specific calibration and matrix-matched quality control material(e.g., to control for instrument variations and mass spectral drift);qualitative or quantitative, all sources, includes specimen validity testing,per day; 8-14 drug class(es), including metabolite(s) if performed.  

Ordering Applications

 

Ordering Application Description
Cerner Targeted Drug Panel, Urine

 

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