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HelpTest Code U-CORT Cortisol, Urinary Free 24 Hour (24 CORT)
Useful For
Urine Free Cortisol is a sensitive test for the various types of adrenocortical dysfunction, particularly hypercortisolism (Cushing’s Syndrome). This test is the preferred screening test for Cushing’s Syndrome. This test has limited usefulness in the evaluation of adrenal insufficiency.
Synonyms/Keywords
24 CORT, Cortisol, Urinary Free, Urinary Free Cortisol
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Urine, 24 Hour | 24 hr urine jug - no preservative | 24 hr urine jug with sulfamic acid preservative | 10 mL aliquot from well mixed 24 hr urine | 5 mL aliquot | 2 mL aliquot |
Collection/Processing Instructions
No special patient preparation is required, but avoid all forms of stress to the patient, since this may cause elevated Urinary Cortisol levels. Indicate collection times. Total volume must be measured, recorded and included with the test request. Due to diurnal variations in urinary cortisol, collection must be 24 hours ± 2 hours.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerate | 1 week |
| Freeze | 1 month |
Rejection Criteria
| Collection must be 24 hours ± 2 hours |
|---|
| Random specimens |
Test Components
24 hour Urine Cortisol
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Urine Free Cortisol is a sensitive test for the various types of adrenocortical dysfunction, particularly hypercortisolism (Cushing’s Syndrome). This test is the preferred screening test for Cushing’s Syndrome. This test has limited usefulness in the evaluation of adrenal insufficiency. Pregnancy values may be elevated to twice the upper limit of normal.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
0-2 years: Reference range not established 3-8 years: 1.4-20.0 ug/24 hours 9-12 years: 2.6-37.0 ug/24 hours 13-17 years: 4.0-56.0 ug/24 hours ≥18 years: 3.5-45.0 ug/24 hours Pediatric ranges based on literature review |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield |
Thursday Samples must be in the performing department by 8am on the day of testing for results the same day |
6-8 hours | UHPLC MS/MS-Waters TQ-XS System |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82530 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 82530 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Cortisol, Urinary Free, 24 Hour |