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HelpTest Code VANCO Vancomycin
Useful For
Vancomycin is a glycopeptide antibiotic that is bactericidal against many gram-positive and some gram-negative cocci.
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum or Plasma | Serum Separator Tube (SST) | Red Top Tube(RTT) or Lithium Heparin Plasma Separator Tube (PST) | 0.5 mL | 0.2 mL | 0.5 mL whole blood |
Collection/Processing Instructions
Sample should be transported to lab on a cold pack (if sample is not on a cold pack it is acceptable as long as separated from cells within 60 minutes).
If sample will not be assayed within 2 hours of collection it should be frozen.
EXACT DRAW TIME must be noted--both on the specimen label and on the request form/computer request.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerate | 2 hours |
| Freeze | 1 year |
Interpretations
1) Vancomycin trough concentrations should always be maintained at >10 ug/mL to avoid the development of resistance.
2) For serious Staphylococcus aureus infections such as septicemia, infective endocarditis, osteomyelitis, meningitis, pneumonia and severe SSTI (necrotizing fascititis), vancomycin trough concentrations of 15-20 ug/mL are recommeneded.
3) Vancomycin induced nephrotoxicity is indicated when serum creatinine increase of 0.5 mg/dL or 50% from baseline (whichever greater) is observed after several days of therapy in the absence of an alternative explanantion. Recommend a minimum of two or three consecutive serum creatinine concentrations to monitor possible nephrotoxicity during the course of therapy.
Trough concentrations are most accurate and recommended for therapeutic monitoring of Vancomycin preferably obtained just prior to the next dose at steady-state condition (just before the fourth dose with normal renal function). Evidence does not support monitoring peak concentrations to decrease the frequency of nephrotoxicity.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| All Performing Sites |
Reference Range: Trough concentrations only Therapeutic concentrations: 10-15 ug/mL Serious infections: 15-20 ug/mL Toxic levels: ≥80 ug/mL |
| See Critical Value List for list of current critical values | |
Marshfield Labs Performing Department
Marshfield Labs Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Beaver Dam | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Weston | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Eau Claire | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Park Falls | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Rice Lake | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Marshfield | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Minocqua | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Neillsville | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
| Stevens Point | Monday through Sunday | Less than 2 hours | Emit* 2000 Rate Assay/Beckman AU |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80202 | 1 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80202 | 1 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Vancomycin Level |