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HelpTest Code ZONI Zonisamide
Useful For
This test is useful for monitoring zonisamide therapy used to control epilepsy
Synonyms/Keywords
Zonegran
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Serum | Red Top Tube (RTT) | 0.5 mL | 0.5 mL | 0.3 mL |
Collection/Processing Instructions
Indicate collection time.
Separate serum/plasma from cells within 2 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | ||
| Refrigerate | 2 weeks | |
| Frozen | 2 weeks |
Rejection Criteria
Specimens collected in a serum or plasma separator tube
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Interpretations
Steady state zonisamide concentration in a trough specimen collected just before the next dose correlates with patient response. Optimal therapeutic response occurs when the trough zonisamide concentration is in the range of 10-40 ug/mL Peak plasma concentration for zonisamide occures 2-6 hours after dose. Time to peak is affected by ingestion of food. Concurrent enzyme inducing anticonvulsants such as phenytoin, carbamazepine or barbiturates stimulate zonisamide metabolism and decrease serum zonisamide levels. Zonisamide has been reported to increase phenytoin and carbamazepine levels.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
10-40 ug/mL Possible toxicity may be observed at concentrations ≥ 60 ug/mL |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday, Wednesday, Friday | 6-8 hours | UPLC MS/MS - Waters Acquity UPLC, XEVO TQ-S Tandem Mass Spectrometry System |
| Samples must be in performing department by 8am on day of testing for results the same day. Testing may be batched and set up on alternative days of the week as needed. | |||
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80203 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 80203 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| COM | Zonisamide |
| Cerner | Zonisamide, Serum |