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Test Code AAT Alpha-1 Antitrypsin

Useful For

The principle clinical interest in AAT levels is in detecting genetic deficiencies that lead to a form of emphysema. Proteolytic enzymes are released by bacteria and other inflammatory cells which are not inhibited and which cause tissue destruction in individuals with AAT deficiency.  If decreased levels are found in individuals with pulmonary disease, genetic phenotyping using starch gel electrophoresis is frequently performed.

Synonyms/Keywords

AAT, Alpha-1-antitrypsin, Alpha trypsin inhibitor, Alpha-1-protease inhibitor

Specimen Requirements

Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No Serum Red Top Tube (RTT) Serum Separator Tube (SST) 0.5 mL 0.4 mL 0.3 mL

Specimen Stability Information

Specimen Type Temperature

Time
Serum Refrigerate 7 days
Frozen 3 months

Rejection Criteria

Plasma samples

Interferences

Pregnancy and oral contraceptives may cause increase in Alpha-1 Antitrypsin

Interpretations

Less than 80 mg/dL is considered clinically at risk for AAT deficiency. Follow-up AAT genotyping (A1ALCSO) is recommended.

Reference Range Information

Performing Location Reference Range
Marshfield 90 - 200 mg/dL

Marshfield Labs Performing Department

Marshfield Labs Immunodiagnostics

Performing Information

Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield Monday through Friday 6-8 hours Turbidimetric method/The Binding Site Optilite analyzer

CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
82103        

Outreach CPT Codes

CPT Modifier
(if needed)		 Quantity Description Comments
82103        

Ordering Applications

Ordering Application Description
Cerner Alpha-1-Antitrypsin
COM Alpha-1-Antitrypsin