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HelpTest Code LAPAN Lupus Anticoagulant Panel
Useful For
Recommended for the evaluation of patients with thrombosis and/or prolonged phospholipid-dependent clotting assays (ex: PT and APTT).
This panel is not recommended to aid in the diagnosis of Systemic Lupus Erythematosis (SLE). Instead, see ANA EIA (ANA HEp-2 Serum Screen).
Synonyms/Keywords
Lupus Inhibitor Work-up, Lupus Inhibitor Panel
Specimen Requirements
| Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|
| *Platelet Poor Plasma | 3.2% Citrated Blue Top Tube (BTT) | One 1.0 mL aliquot | 0.75 mL | 0.5 mL |
Collection/Processing Instructions
One 1.0 mL citrated Blue Top Tube (BTT) plasma aliquot. (If other coagulation tests are ordered, a separate aliquot is needed for each test.)
- Collect in Citrated Blue Top Tube (BTT)
- Citrate anticoagulant must be adjusted for HCT >55%
- Tubes must be at least 90% full
- Invert completely 3-4 times (without shaking) to mix
*See Instructions for: Preparation of Platelet Poor Plasma
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma | Room Temp | 4 hours |
| Refrigerated | 4 hours | |
| Frozen | 6 months |
Rejection Criteria
| Clotted or Hemolyzed |
|---|
| Contamination with IV or Hickman Line fluids |
| Specimens that thaw during storage or transport |
Test Components
Dilute Russell Viper Venom Time (DRVVT), Silica Clotting Time (SCT)
Test Information
The detection of a lupus anticoagulant, a heterogeneous group of antibodies, is enhanced by performing two or more screening tests. Therefore, the LUPUS ANTICOAGULANT PANEL includes both a DRVVT and SCT. If results of either or both tests are positive for LA, a lupus anticoagulant is present. Platelet poor plasma plasma platelet count must be less than 10,000/uL. Test results may be falsely negative due to the presence of excess platelets in the plasma.
Requested panel includes Lupus anticoagulant testing (DRVVT and SCT), these tests should not be performed on patients receiving rivaroxaban, apixaban, dabigatran, or warfarin. For patients on these medications, order the anticardiolipin antibody and/or anti-beta-2 glycoprotein 1 antibody tests individually instead of the panel.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | See individual test listings for reference ranges. |
Marshfield Labs Performing Department
Marshfield Labs Coagulation
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday and Thursday | Less than 2 hours | Optical clot detection/ACL TOP 550 |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 85613 | Dilute Russell Viper Venom Time |
Optical Clot Detection |
||
| 85732 | Silica Clotting Time | Optical Clot Detection |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 85613 | Dilute Russell Viper Venom Time | Optical Clot Detection | ||
| 85732 | Silica Clotting Time | Optical Clot Detection |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Lupus Anticoagulant Panel |