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HelpTest Code MET Metanephrines, Urine 24 Hour (24 MET)
Useful For
Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as "metanephrines", together with plasma metanephrine levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma. 24-hr urine is highly recommended.
Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors
Synonyms/Keywords
24 MET, Metanephrine, Normetanephrine; Metanephrine Fractionation
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Urine | 24 hr urine jug with 7 g sulfamic acid preservative | 24 hr urine jug with 20 mL 6N HCl |
10 mL aliquot from a well mixed 24 hr urine | 5 mL aliquot | 5 mL aliquot |
Collection/Processing Instructions
Indicate collection dates and times. Total volume must be measured, recorded and included with the test request.
Urine must be preserved for the entire collection. Add acid preservative to collection jug prior to start of collection.
If urine was not collected for a 22-26 hour duration, sample will be rejected and ordering provider notified. The appropriate test to order for samples collected of duration less than 22 hours is "Metanephrine Fractionation, Urine Random" (U MET)(MET-RND).
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine (preserved) | Refrigerate | 1 week |
| Frozen | 1 week |
Rejection Criteria
Specimens that are improperly preserved.
Specimens that are unpreserved.
Urine collected for durations other than 22-26 hours
Test Components
24 hour Urine Metanephrine, Normetanephrine and Creatinine
Test Information
Patient results determined by other methods may not be comparable.
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Interferences
Patients should be off Buspirone (Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.
Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
Normetanephrine: 50-840 ug/24 hr Metanephrine: 0-370 ug/24 hr Reference ranges are based on hypertensive population results |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield |
Monday, Wednesday, Friday Samples must be in the performing department by 8am on the day of testing for results the same day |
6-8 hours |
Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83835 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83835 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Metanephrines, Urine 24 Hour |