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HelpTest Code MET-RND Metanephrine Fractionation, Urine Random (U MET)
Useful For
Quantitation of urine normetanephrine (NMN) and metanephrine (MN), collectively referred to as 'metanephrines', together with plasma metanephrine levels is useful as the initial screen to aid in the diagnosis and follow-up of catecholamine-producing tumors, pheochromocytoma and paraganglioma.
24-hr urine is highly recommended. (See test code MET for further details on 24 hour urine testing)
Biochemical Evaluation and Diagnosis of Catecholamine-producing Tumors
Synonyms/Keywords
U MET, Metanephrine, Normetanephrine; Metanephrines/Creatinine Ratio
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Urine | Sage cup with 0.1 g sulfamic acid | 50 mg sulfamic acid aliquot tube or acidify with dilute hydrochloric acid to a pH <5 | 10 mL | 5 mL urine | 5 mL urine |
Collection/Processing Instructions
Urine must be preserved immediately at the time of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine (preserved) | Refrigerate | 1 week |
| Frozen | 1 week |
Rejection Criteria
Specimens that are unpreserved.
Test Components
Urine Metanephrine, Normetanephrine and Creatinine give a Metanephrine/Creatinine Ratio
Test Information
Patient results determined by other methods may not be comparable.
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Interferences
Patients should be off Buspirone ("Buspar") for 72 hours before collection as the drug may cause false elevations of metanephrine.
Patients should be off of Sinemet (Levodopa or Carbidopa), L-Dopa, Aldomet (Methyldopa) and methanamine mandelate (Hiprex, Mandelamine, Urex) for 1 week (minimum of 48 hours) prior to collection.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield |
Normetanephrine: 69-750 ug/g creatinine Metanephrine: 27-270 ug/g creatinine |
Marshfield Labs Performing Department
Marshfield Labs Special Chemistry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield |
Monday, Wednesday, Friday Samples must be in the performing department by 8am on the day of testing for results the same day |
6-8 hours | Waters Acquity UPLX XEVO TQ-S Tandem Mass Spectrometry System |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83835 |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 83835 |
Ordering Applications
| Ordering Application | Description |
|---|---|
| Cerner | Metanephrine Fractionated, Urine Random |