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HelpTest Code NK Natural Killer (CD16, CD56, CD57) Profile
Useful For
Changes in the NK profile may be useful to monitor the response to therapy in Lyme disease. If monitoring by CD57 only is desired, order CD57 test code.
Natural killer cells are a subset of the lymphocyted population. To quantitate all subsets (including T-cells, B-cells & NK cells), see test code TBNK (Immune Deficiency Cell Markers).
If a large granular lymphocyte proliferation is suspected, see test code FLOW (Flow Cytometry Immunophenotyping).
Call Flow Cytometry (800-222-5835 ext. 16385) for more information.
Synonyms/Keywords
Flow Cytometry
Specimen Requirements
| Fasting Required | Specimen Type | Preferred Container/Tube | Acceptable Container/Tube | Specimen Volume | Specimen Minimum Volume (allows for 1 repeat) |
Pediatric Minimum Volume (no repeat) |
|---|---|---|---|---|---|---|
| No | Whole blood | EDTA | Sodium-heparin Green Top Tube (GTT) | 1.0 mL | 1.0 mL | 0.5 mL |
Collection/Processing Instructions
If a CBC with differential has been performed within 4 hours of the collection for the NK Profile, please send a copy of the CBC with differential results along with the NK Profile specimen. If a CBC with differential has not been performed in this time period, include an order for the CBC with differential. This requires a separate EDTA whole blood (LTT) and two unstained EDTA smears.
Notify Flow Cytometry Lab (800-222-5835, ext. 16385) before sending the specimen.
Specimen must arrive in Flow Cytometry within 48 hours of collection.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole blood | Room temperature | 72 hours |
Rejection Criteria
| Fixed specimens |
|---|
| Specimens greater than 72 hours old |
| Refrigerated or frozen specimens |
| **Contact Flow Cytometry for suitability prior to rejection of any specimens.** |
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Absolute counts for this test are based on the CBC results provided at the time of testing, including lymphocyte percentage.
Reference Range Information
| Performing Location | Reference Range |
|---|---|
| Marshfield | Not applicable |
Marshfield Labs Performing Department
Marshfield Labs Flow Cytometry
Performing Information
| Performing Location | Day(s) Test Performed | Analytical Time | Methodology/Instrumentation |
|---|---|---|---|
| Marshfield | Monday through Friday | 1 day | Flow Cytometry |
CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 88184 | 1 | Flow Cytometry, first marker | ||
| 88185 | 3 | Additional marker, each |
Outreach CPT Codes
| CPT | Modifier (if needed) |
Quantity | Description | Comments |
|---|---|---|---|---|
| 88184 | 1 | Flow Cytometry, first marker | ||
| 88185 | 3 | Additional marker, each |